Taxpayers are expected to save billions after the Biden administration inked deals with pharmaceutical companies to knock down the lists prices for 10 of Medicare’s costliest drugs.

But how much older Americans can expect to save when they fill a prescription at their local pharmacy remains unclear, since the list cost isn’t the final price people pay.

After months of negotiations with manufacturers, list prices will be reduced by hundreds — in some cases, thousands — of dollars for 30-day supplies of popular drugs used by millions of people on Medicare, including blood thinners, diabetes drugs and blood cancer medications. The reductions, which range between 38% and 79%, take effect in 2026.

“I’ve been waiting for this moment for a long long time,” President Joe Biden said Thursday, during his first policy-oriented appearance with Vice President Kamala Harris since leaving the presidential race. “We pay more for prescription drugs, it’s not hyperbole, than any advanced nation in the world.”

Taxpayers spend more than $50 billion yearly on the 10 drugs, which include popular blood thinners Xarelto and Eliquis and diabetes drugs Jardiance and Januvia.

With the new prices, the administration says savings are expected to total $6 billion for taxpayers and $1.5 billion overall for some of the 67 million people who rely on Medicare. Details on those calculations, however, have not been released. And the White House said it could not provide an average cost-savings for individual Medicare enrollees who use the drugs.

That’s because there are a number of factors — from discounts to the coinsurance or copays for the person’s Medicare drug plan — that determine the final price a person pays when they pick up their drugs at a pharmacy.

The Biden administration says Medicare recipients will save about $1.5 billion on out-of-pocket costs for medications to treat diabetes, heart disease, types of arthritis and other ailments under new prices negotiated with drug companies that will take effect in 2026.

The savings range from 79% for Januvia, used to manage diabetes, to 38% for Imbruvica, which is used to treat blood cancers. That is the medication’s cost before any discounts or rebates are applied, but not what the price people actually pay when filling their prescriptions.

A look at the drugs and the negotiated prices.

Januvia

Manufacturer: Merck Sharp Dohme

Conditions: Diabetes

Negotiated price: $113 for a 30-day supply

Reduction: 79%

Fiasp; Fiasp FlexTouch; Fiasp PenFill; NovoLog; NovoLog FlexPen; NovoLog PenFill:

Manufacturer: Novo Norodisk

Conditions: Diabetes

Negotiated price: $119 for a 30- day supply

Reduction: 76%

Farxiga

Manufacturer: AstraZeneca AB.

Conditions: Diabetes, heart failure and chronic kidney disease

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Negotiated price: $178.50 for a 30-day supply

Reduction: 68%

Enbrel

Manufacturer: Immunex Corp.

Conditions: Rheumatoid arthritis, psoriasis and psoriatic arthritis

Negotiated price: $2,355 for a 30-day supply

Reduction: 67%

Jardiance

Manufacturer: Boehringer Ingelheim

Conditions: Diabetes, heart failure and chronic kidney disease

Negotiated price: $197 for a 30-day supply

Reduction: 66%

Stelara

Manufacturer: Janssen Biotech Inc.

Conditions: Psoriasis, psoriatic arthritis, Crohn’s disease, ulcerative colitis

Negotiated price: $4,695 for a 30-day supply

Reduction: 66%

Xarelto

Manufacturer: Janssen Pharms

Conditions: Prevention and treatment of blood clots. Reduction of risk for patients with coronary or peripheral artery disease

Negotiated price: $197 for a 30-day supply

Reduction: 62%

Eliquis

Manufacturer: Bristol Myers Squibb

Conditions: Prevention and treatment of blood clots

Negotiated price: $231 for a 30-day supply

Reduction: 56%

Entresto

Manufacturer: Novartis Pharms Corp

Conditions: Heart failure

Negotiated price: $295 for a 30-day supply

Reduction: 53%

Imbruvica

Manufacturer: Pharmacyclics LLC

Conditions: Blood cancers

Negotiated price: $9,319 for a 30-day supply

Savings: 38%

“It is hard to say, exactly, what any enrollee will save because it depends on their particular plan and their coinsurance,” said Tricia Neuman, an executive director at the health policy research nonprofit KFF.

Those savings won’t kick in until 2026. Until then, some Medicare enrollees should see relief from drug prices in a new rule starting next year that caps how much they pay annually on drugs to $2,000.

Vice President Kamala Harris, however, wasted no time Thursday campaigning on the new drug deals, especially since no Republicans supported the law, called the Inflation Reduction Act (IRA), and it barely passed Congress in 2022.

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